Tupelo, MS Business Opportunities

North Mississippi Medical Center in Tupelo, MS
North Mississippi Medical Center in Tupelo, MS

Located at the intersection of U.S. highways 45 and 78, Tupelo is roughly equidistant from Memphis, Tenn. and Birmingham, Ala. along one axis and Nashville, Tenn. and Jackson, Miss. along another. In addition to these highways, interstate transportation is facilitated by two rail lines (the Burlington Northern Santa Fe and the Kansas City Southern) and the Tupelo Regional Airport. The following is a sample of the major business entities in Tupelo.

Health Care

Tupelo is home to North Mississippi Medical Center, which is the largest non-metropolitan hospital in the U.S. The center provides 650 beds and 400 doctors who cover 39 medical specialties. Employing approximately 4,000 people, the center is the largest employer in Tupelo.

Retail Exhibition

Tupelo is home to three distinct areas that offer exceptional product exhibition areas. The Mall at Barnes Crossing features a 600-seat food court, a movie theater and more than 90 stores that include such well-known names as Ann Taylor Loft, Dick's Sporting Goods and Barnes and Noble, to name a few. With the crowds these retailers draw, annual sales for the mall regularly reach more than $175 million.

Next, the Tupelo Furniture Market was created in 1993 with the purchase of the Mississippi National Furniture Market. Located in the upholstery capital of the world, the market features 2 million square feet of space showing 800-1,000 exhibitors from around the world.

Lastly, the Downtown and Fairpark District features a 50-acre site next to downtown Tupelo. The district is being redeveloped by the Tupelo Redevelopment Agency using a $22.7 million investment generated by city bonds. The redeveloped area will incorporate the same architectural character and scale as downtown Tupelo to remain aesthetically consistent.


Tupelo has been home to two national banks' headquarters for over 100 years. With more than 300 locations in eight states, BancorpSouth holds more than $13 billion in assets and regularly earns roughly $1 billion in annual revenue. BancorpSouth gives back to the community that fostered its success by sponsoring the 10,000 seat, multipurpose arena in downtown Tupelo called BancorpSouth Arena.

With locations in three states, Renasant Bank holds nearly $4 billion in assets. Drawing on its success in banking, Renasant Bank created the Renasant Center for IDEAs to help small businesses thrive in today's global economy. The center accomplishes this goal by providing productive services and resources that help small businesses design, develop, and distribute products or services to the community.

The center features workshop spaces with roll-up doors and open spaces that can be tailored to suit the needs of various enterprises, such as laboratories or call centers. The center's amenities include a kitchen restaurant, pantry, dining room and outdoor eating area.

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