UPDATE: Check out our new 2023 Best Cities to Live in the U.S. list.
#21. Sioux Falls
South Dakota entrepreneurship is on the rise, and no more so than in Sioux Falls, the largest city in the state. Thanks to the recent addition of a new angel fund, Falls Angel Fund LLC, startup culture looks to continue to grow in this Midwest city.
Business Growth (2011-2015): 7%
Employment Growth (2011-2015): 4%
