People cross the street in downtown Ann Arbor in front of a store called The M Den

UPDATE: Check out our new 2023 Best Cities to Live in the U.S. list.

#6. Ann Arbor

Entrepreneurs looking for advice have many choices here. For example, Ann Arbor SPARK is the city’s economic development department that hosts an annual Spring Entrepreneurial Boot Camp and a Fall Entrepreneurial Boot Camp. Meanwhile, a Center for Entrepreneurship is in place at the University of Michigan’s College of Engineering. But what’s the quality of life like in Ann Arbor? Let’s just say it has made our 100 Best Places to Live list three years in a row, now.

Business Growth (2011-2015): 13%

Employment Growth (2011-2015): 12%

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