#22. Minneapolis

Sitting on both banks of the mighty Mississippi River is Minneapolis, Minn., a global city that serves as the primary business center between Chicago and Seattle. The city is an ideal setting for entrepreneur companies, including the brewery industry that now provides residents and visitors with nearly 30 locales. Top spots include Dangerous Man Brewing Co., Sisyphus Brewing and Surly Brewing Co., which offers flavors like Bitter Brewer and CynicAle that are as bitter as their names would suggest.

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